The approval, along with endorsement for an $85 million apartment and commercial building in East Fremantle, brings the total value of 23 applications approved through the Part 17 pathway since it opened in July 2020 to more than $3.14 billion.
In total, the 23 applications are expected to support almost 17,000 jobs.
The hospital and East Fremantle developments are two of seven State-significant applications worth more than $824 million expected to be considered by the WAPC over the next few months.
The hospital redevelopment includes a nine-storey clinical block, 11-storey medical suites and research building, and a two-storey addition to the existing multi-storey car park.